Dr. David Labbé @ Montreal Epigenetics Seminar Series

Host: Professors Serge McGraw & Noel Raynal (University of Montreal)  

Speaker: Dr. David Labbé
Associate Professor
Department of Surgery, Division of Urology
McGill University

Title: MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

Summary: Androgen receptor (AR) and MYC are key to prostate cancer etiology but our current understanding of their interplay is scarce. By integrating “omics” (e.g., bulk and single-cell RNA-seq, ChIP-seq) from a transgenic mouse model of prostate cancer with human tumour transcriptional profiling and clinical data, we show that the oncogenic transcription factor MYC can pause the transcriptional program of the master transcription factor in prostate cancer, AR, while turning on its own, even more lethal program. Our findings suggest that MYC overexpression antagonizes the canonical AR transcriptional program and contributes to prostate tumour initiation, therapy resistance and progression by disrupting transcriptional pause release at AR-regulated genes.

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